Genetic Tools (Addgene)
Journal Articles
20. “Thioglycoside functionalization via chemoselective phosphine acceleration of a photocatalytic thiol-ene reaction.” Arun K. Thangarasu and Charlie Fehl. Chemical Communications (2025) 61: 9484-9487.
19. “A reference dataset of O-GlcNAc proteins in quadriceps skeletal muscle from mice.” Ruchi Jaiswal, Yimin Liu, Ziangmin Zhang, Michael Petriello, Zhengping Yi, Charlie Fehl. Glycobiology (2025) 35: cwaf005. doi.org/10.1093/glycob/cwaf005
18. “Adipose microenvironment promotes hypersialylation of ovarian cancer cells.” Garry Leonard (co-first authors), Nicholas Adzibolosu, Roslyn Tedja, Charlie Fehl*, and Ayesha Alvero* (co-correspondence). Frontiers in Oncology (2024) 14: 1432333. doi.org/10.3389/fonc.2024.1432333
17. “GlycoID Proximity Labeling to Identify O-GlcNAcylated Protein Interactomes in Live Cells.” Zachary M. Nelson, Oseni Kadiri, and Charlie Fehl. Current Protocols in Chemical Biology (2024). doi.org/10.1002/cpz1.1052
16. “Tools for investigating O-GlcNAc in signaling and other fundamental biological pathways.” Zachary M. Nelson, Garry D. Leonard, and Charlie Fehl. Journal of Biological Chemistry (2024) 300: pg. 105615. DOI: 10.1016/j.jbc.2023.105615
15. “Hyperglycemia and O-GlcNAc transferase activity drive a cancer stem cell pathway in triple-negative breast cancer.” Saheed Ayodeji, Emily A. Teslow, Lisa A. Polin, Greg Dyson, Aliccia Bollig-Fischer, and Charlie Fehl. Cancer Cell International (2023) 23: article number 102. DOI: 10.1186/s12935-023-02942-6
14. “Spatiotemporal Proximity Labeling Tools to Track GlcNAc Sugar-Modified Functional Protein Hubs during Cellular Signaling.” Yimin Liu, Zachary M. Nelson, Ali Reda, and Charlie Fehl. ACS Chemical Biology (2022) 17: 2153. DOI: https://doi.org/10.1021/acschembio.2c00282
13. “Synthesis and mammalian cell compatibility of light-released glycan precursors for controlled metabolic engineering.” Courtney A. Kondor, Jaggaiah N. Gorantla, Garry D. Leonard, and Charlie Fehl. Bioorganic & Medicinal Chemical (2022) 70: 116918. DOI: https://doi.org/10.1016/j.bmc.2022.116918
12. “Tools, Tactics, and Objectives to Interrogate Cellular Roles of O-GlcNAc in Disease.” Charlie Fehl and John A. Hanover. Nature Chemical Biology (2022) 18: 8-17. DOI: https://doi.org/10.1038/s41589-021-00903-6
11. “Chemical Synthesis and Biological Applications of O-GlcNAcylated Peptides and Proteins.” Groenevelt, Jessica M.; Corey, Daniel J.; Fehl, Charlie. ChemBioChem (2021) 22: 1854-1870. DOI: 10.1002/cbic.202000843
10. “Mild, Light-Driven, Posttranslational Installation of Reactive Protein Side-Chains.” Josephson, Brian*; Fehl, Charlie*; Iseneggar, Patrick* [*equal contributors]; Nadal, Simon; Wright, Tom H.; Poh, Adeline W.J.; Bower, Ben J.; Giltrap, Andrew M.; Chen, Lifu; Batchelor-McAuley, Christopher; Roper, Grace; Arisa, Oluwatobi; Sap, Jeroen B.I.; Kawamura, Akane; Baldwin, Andrew; Mohammed, Shabaz; Compton, Richard G.; Gouverneur, Veronique; Davis, Benjamin. G. Nature (2020) 585: 530. DOI: 10.1038/s41586-020-2733-7
9. “Functional and informatics analysis enables glycosyltransferase activity prediction.” Yang, Min*; Fehl, Charlie* [*equal contributors]; Lees, Karen V.; Lim, Eng-Kiat; Offen, Wendy; Davies, Gideon J.; Bowles, Dianna J.; Roberts, Stephen J.; Davis, Benjamin G. Nature Chemical Biology, 14, 1109. (2018). DOI: 10.1038/s41589-018-0154-9
8. “Structure-based design of inhibitors with improved selectivity for steroidogenic cytochrome P450 17A1 over cytochrome P450 21A2.” Fehl, Charlie; Vogt, Caleb; Yadav, Rahul; Li, Kelin; Scott, Emily E.; Aubé, Jeffrey. J. Med. Chem. 2018, 61, 4946. DOI: 10.1021/acs.jmedchem.8b00419
7. “Proteins as templates for complex synthetic metalloclusters: towards biologically programmed heterogeneous catalysis.” Fehl, Charlie; Davis, Benjamin G. Proc. Royal Soc. A: Math. Phys. Eng. Sci. 2016, 472, 20160078. DOI: 10.1098/rspa.2016.0078
6. “Outperforming Nature’s Catalysts: Designing Metalloenzymes for Chemical Synthesis.” Fehl, Charlie; Jarvis, Amanda G.; Palm-Espling, Maria; Davis, Benjamin G.; Kamer, Paul C.J. In Modern Developments in Catalysis; World Scientific Press: Singapore, 2016; 89-122.
5. “Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction.” Fehl, Charlie; Hirt, Erin. E.; Li, Sze-Wan; Aubé, Jeffrey. Tetrahedron Lett. 2015, 56, 3137. DOI: 10.1016/j.tetlet.2014.12.068
4. “Photocatalytic surface patterning of cellulose using diazonium salts and visible light.” Schroll, Peter; Fehl, Charlie; Dankesreiter, Stefan; König, Burkhard. Org. Biomol. Chem. 2013, 11, 6510. DOI: 10.1039/c3ob40990b
3. “Overcoming product inhibition in catalysis of the intramolecular Schmidt reaction.” Motiwala, Hashim F.; Fehl, Charlie; Li, Sze-Wan; Hirt, Erin E.; Porubsky, Patrick; Aubé, Jeffrey. J. Am. Chem. Soc. 2013, 135, 9000. DOI: 10.1021/ja402848c
2. “Hofmann, Curtius, Schmidt, Lossen and Related Reactions.” Fehl, Charlie; Liu, Ruzhang; McCleod, Michael; Motiwala, Hashim; Aubé, Jeffrey. In Comprehensive Organic Synthesis, 2nd Ed; Elsevier Limited: Amsterdam, 2014; 598-635.
1. “Use of a tandem Prins/Friedel-Crafts reaction in the construction of the indeno-tetrahydropyridine core of the haouamine alkaloids: formal synthesis of (-)-haouamine A.” Fenster, Erik; Fehl, Charlie; Aubé, Jeffrey. Org. Lett. 2011, 13, 2614. DOI: 10.1021/ol200725m
Patents
4. “GLYCAN DETECTION METHODS, COMPOSITIONS, AND APPLICATIONS THEREOF.” Oseni Kadiri, Yimin Liu, and Charlie Fehl. United States Provisional Patent, filed Jun 28, 2024. (number 63/665,986)
3. “Glycan Proximity Labeling Methods and Applications Thereof.” Zachary M. Nelson and Charlie Fehl. WO2025/007142A2 (January 2, 2025).
2. “Controlled Glycan Metabolic Engineering Systems and Applications Thereof.” Courtney Kondor, Jaggaiah Gorantla, Garry Leonard, and Charlie Fehl. WO2025/007135A2 (January 2, 2025).
1. “Inhibitors of CYP17A1.” Fehl, Charlie; Scott, Emily E.; Aubé, Jeffrey. United States Patent 9,611,270. (April 4, 2017)