Journal Articles

7.  “Functional screening and chemo-bioinformatic analysis allows rationalization and activity prediction within a broad protein family.” Yang, Min*;  Fehl, Charlie* [*equal contributors]; Lees, Karen V.; Lim, Eng-Kiat; Offen, Wendy; Davies, Gideon J.; Bowles,  Dianna J.; Roberts, Stephen J.; Davis, Benjamin G. Nature Chemical Biology, Accepted (2018).

6. “Structure-based design of inhibitors with improved selectivity for steroidogenic cytochrome P450 17A1 over cytochrome P450 21A2.” Fehl, Charlie; Vogt, Caleb; Yadav, Rahul; Li, Kelin; Scott, Emily E.; Aubé, Jeffrey. J. Med. Chem. 2018, 61, 4946. DOI: 10.1021/acs.jmedchem.8b00419

5. “Proteins as templates for complex synthetic metalloclusters: towards biologically programmed heterogeneous catalysis.” Fehl, Charlie; Davis, Benjamin G. Proc. Royal Soc. A: Math. Phys. Eng. Sci. 2016, 472, 20160078. DOI: 10.1098/rspa.2016.0078

4. “Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction.” Fehl, Charlie; Hirt, Erin. E.; Li, Sze-Wan; Aubé, Jeffrey. Tetrahedron Lett. 201556, 3137. DOI: 10.1016/j.tetlet.2014.12.068

3. “Photocatalytic surface patterning of cellulose using diazonium salts and visible light.” Schroll, Peter; Fehl, Charlie; Dankesreiter, Stefan; König, Burkhard. Org. Biomol. Chem. 201311, 6510. DOI: 10.1039/c3ob40990b

2.  “Overcoming product inhibition in catalysis of the intramolecular Schmidt reaction.” Motiwala, Hashim F.; Fehl, Charlie; Li, Sze-Wan; Hirt, Erin E.; Porubsky, Patrick; Aubé, Jeffrey. J. Am. Chem. Soc. 2013135, 9000. DOI: 10.1021/ja402848c

1. “Use of a tandem Prins/Friedel-Crafts reaction in the construction of the indeno-tetrahydropyridine core of the haouamine alkaloids: formal synthesis of (-)-haouamine A.” Fenster, Erik; Fehl, Charlie; Aubé, Jeffrey. Org. Lett. 201113, 2614. DOI: 10.1021/ol200725m


Book chapters

2. “Outperforming Nature’s Catalysts: Designing Metalloenzymes for Chemical Synthesis.” Fehl, Charlie; Jarvis, Amanda G.; Palm-Espling, Maria; Davis, Benjamin G.; Kamer, Paul C.J. In Modern Developments in Catalysis; World Scientific Press: Singapore, 2016; 89-122.

1. “Hofmann, Curtius, Schmidt, Lossen and Related Reactions.” Fehl, Charlie; Liu, Ruzhang; McCleod, Michael; Motiwala, Hashim; Aubé, Jeffrey. In Comprehensive Organic Synthesis, 2nd Ed; Elsevier Limited: Amsterdam, 2014; 598-635.



1. “Inhibitors of CYP17A1.” Fehl, Charlie; Scott, Emily E.; Aubé, Jeffrey. United States Patent 9,611,270. (April 4, 2017)