Genetic Tools (Addgene)
Journal Articles
25. “Chemical Biology Tools for the O-GlcNAc Modification: Determining Systems-Level Functions and Druggability.” Charlie Fehl. Current Opinion in Chemical Biology (2026), accepted.
24. “Single-Nuclei RNA Sequencing Reveals Obesity-Associated Rewiring of Estrogen Signaling in Endometrioid Adenocarcinoma.” Jessica Long, Sophia Agrusa, Sworna Pukhrambam, Sanjeev Ganesh, Mark Gregory, Areebah Qazi, Myegenet Faris, Anna Gottschlich, Ayesha Alvero, Charlie Fehl, Robert T Morris, John J Wallbillich, Heather M Gibson, Katherine Gurdziel, Julie Boerner, & Mike R Wilson. iScience (2026), accepted.
23. “High-resolution microtesla in-situ 13C NMR detection of “scaled-up” SABRE-hyperpolarization of [1-13C]pyruvate.” Abubakar Abdurraheem, Joseph N. Gyesi, Shiraz Nantogma, Patrick TomHon, Anna Samoilenko, Clementinah Oladun, Boyd M. Goodson, Matthew S. Rosen, Thomas Theis, Charlie Fehl, Eduard Y. Chekmenev. Journal of Magnetic Resonance (2026) 391: 108120. doi: https://doi.org/10.1016/j.jmr.2026.108120
22. “A Scalable Design for Proximity-Inducing Molecules.” Endri Karaj, Varsha Venkatarangan, Shaimaa H. Sindi, Surached Siriwongsup, Chaiheon Lee, Rajaiah Pergu, Vedagopuram Sreekanth, Karishma Kailass, Kien Tran, Prashant Singh, Sameek Singh, Junya Kawai, Jeffrey E. Fung, Mahilet Tefera, Rohil Dhaliwal, Santosh K. Chaudhary, April Keyes, Ananthan Sadagopan, Lisa Boatner, Neel H. Shah, Charlie Fehl, Keriann M. Backus, and Amit Choudhary. bioRxiv (2026); awaiting reviewer feedback. doi: https://doi.org/10.64898/2026.02.20.706349
21. “Robust Rapid Cellular Metabolite Sensing Using Benchtop NMR and SABRE-Hyperpolarized [1-13C]Pyruvate.” Joseph Gyesi, Patrick TomHon, Abubakar Abdurraheem, Anna Samoilenko, Sydney Scofield, Clementinah Oladun, Stephen McBride, Erica Curran, Megan Pike, Kamal Kadari, Sydney D Welch, Sam Lipka, Steven Balboa, Charlie Fehl, Marianna Sadagurski, Jan-Bernd Hövener, Thomas Theis, Boyd M Goodson, and Eduard Y Chekmenev. Analytical Chemistry (2026) 98:8051–8059. doi: 10.1021/acs.analchem.5c05076
20. “Thioglycoside functionalization via chemoselective phosphine acceleration of a photocatalytic thiol-ene reaction.” Arun K. Thangarasu and Charlie Fehl. Chemical Communications (2025) 61: 9484-9487. doi: https://doi.org/10.1039/d5cc00131e
19. “A reference dataset of O-GlcNAc proteins in quadriceps skeletal muscle from mice.” Ruchi Jaiswal, Yimin Liu, Ziangmin Zhang, Michael Petriello, Zhengping Yi, Charlie Fehl. Glycobiology (2025) 35: cwaf005. doi.org/10.1093/glycob/cwaf005
18. “Adipose microenvironment promotes hypersialylation of ovarian cancer cells.” Alexandra Fox + Garry Leonard (co-first authors), Nicholas Adzibolosu, Terrence Wong, Roslyn Tedja, Sapna Sharma, Radhika Gogoi, Robert Morris, Gil Mor, Charlie Fehl*, and Ayesha Alvero* (co-correspondence). Frontiers in Oncology (2024) 14: 1432333.doi.org/10.3389/fonc.2024.1432333
17. “GlycoID Proximity Labeling to Identify O-GlcNAcylated Protein Interactomes in Live Cells.” Zachary M. Nelson, Oseni Kadiri, and Charlie Fehl. Current Protocols in Chemical Biology (2024). doi.org/10.1002/cpz1.1052
16. “Tools for investigating O-GlcNAc in signaling and other fundamental biological pathways.” Zachary M. Nelson, Garry D. Leonard, and Charlie Fehl. Journal of Biological Chemistry (2024) 300: pg. 105615. DOI: 10.1016/j.jbc.2023.105615
15. “Hyperglycemia and O-GlcNAc transferase activity drive a cancer stem cell pathway in triple-negative breast cancer.” Saheed Ayodeji, Emily A. Teslow, Lisa A. Polin, Greg Dyson, Aliccia Bollig-Fischer, and Charlie Fehl. Cancer Cell International (2023) 23: article number 102. DOI: 10.1186/s12935-023-02942-6
14. “Spatiotemporal Proximity Labeling Tools to Track GlcNAc Sugar-Modified Functional Protein Hubs during Cellular Signaling.” Yimin Liu, Zachary M. Nelson, Ali Reda, and Charlie Fehl. ACS Chemical Biology (2022) 17: 2153. DOI: https://doi.org/10.1021/acschembio.2c00282
13. “Synthesis and mammalian cell compatibility of light-released glycan precursors for controlled metabolic engineering.” Courtney A. Kondor, Jaggaiah N. Gorantla, Garry D. Leonard, and Charlie Fehl. Bioorganic & Medicinal Chemical (2022) 70: 116918. DOI: https://doi.org/10.1016/j.bmc.2022.116918
12. “Tools, Tactics, and Objectives to Interrogate Cellular Roles of O-GlcNAc in Disease.” Charlie Fehl and John A. Hanover. Nature Chemical Biology (2022) 18: 8-17. DOI: https://doi.org/10.1038/s41589-021-00903-6
11. “Chemical Synthesis and Biological Applications of O-GlcNAcylated Peptides and Proteins.” Groenevelt, Jessica M.; Corey, Daniel J.; Fehl, Charlie. ChemBioChem (2021) 22: 1854-1870. DOI: 10.1002/cbic.202000843
10. “Mild, Light-Driven, Posttranslational Installation of Reactive Protein Side-Chains.” Josephson, Brian*; Fehl, Charlie*; Iseneggar, Patrick* [*equal contributors]; Nadal, Simon; Wright, Tom H.; Poh, Adeline W.J.; Bower, Ben J.; Giltrap, Andrew M.; Chen, Lifu; Batchelor-McAuley, Christopher; Roper, Grace; Arisa, Oluwatobi; Sap, Jeroen B.I.; Kawamura, Akane; Baldwin, Andrew; Mohammed, Shabaz; Compton, Richard G.; Gouverneur, Veronique; Davis, Benjamin. G. Nature (2020) 585: 530. DOI: 10.1038/s41586-020-2733-7
9. “Functional and informatics analysis enables glycosyltransferase activity prediction.” Yang, Min*; Fehl, Charlie* [*equal contributors]; Lees, Karen V.; Lim, Eng-Kiat; Offen, Wendy; Davies, Gideon J.; Bowles, Dianna J.; Roberts, Stephen J.; Davis, Benjamin G. Nature Chemical Biology, 14, 1109. (2018). DOI: 10.1038/s41589-018-0154-9
8. “Structure-based design of inhibitors with improved selectivity for steroidogenic cytochrome P450 17A1 over cytochrome P450 21A2.” Fehl, Charlie; Vogt, Caleb; Yadav, Rahul; Li, Kelin; Scott, Emily E.; Aubé, Jeffrey. J. Med. Chem. 2018, 61, 4946. DOI: 10.1021/acs.jmedchem.8b00419
7. “Proteins as templates for complex synthetic metalloclusters: towards biologically programmed heterogeneous catalysis.” Fehl, Charlie; Davis, Benjamin G. Proc. Royal Soc. A: Math. Phys. Eng. Sci. 2016, 472, 20160078. DOI: 10.1098/rspa.2016.0078
6. “Outperforming Nature’s Catalysts: Designing Metalloenzymes for Chemical Synthesis.” Fehl, Charlie; Jarvis, Amanda G.; Palm-Espling, Maria; Davis, Benjamin G.; Kamer, Paul C.J. In Modern Developments in Catalysis; World Scientific Press: Singapore, 2016; 89-122. DOI: doi.org/10.1142/9781786341228_0003
5. “Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction.” Fehl, Charlie; Hirt, Erin. E.; Li, Sze-Wan; Aubé, Jeffrey. Tetrahedron Lett. 2015, 56, 3137. DOI: 10.1016/j.tetlet.2014.12.068
4. “Photocatalytic surface patterning of cellulose using diazonium salts and visible light.” Schroll, Peter; Fehl, Charlie; Dankesreiter, Stefan; König, Burkhard. Org. Biomol. Chem. 2013, 11, 6510. DOI: 10.1039/c3ob40990b
3. “Overcoming product inhibition in catalysis of the intramolecular Schmidt reaction.” Motiwala, Hashim F.; Fehl, Charlie; Li, Sze-Wan; Hirt, Erin E.; Porubsky, Patrick; Aubé, Jeffrey. J. Am. Chem. Soc. 2013, 135, 9000. DOI: 10.1021/ja402848c
2. “Hofmann, Curtius, Schmidt, Lossen and Related Reactions.” Fehl, Charlie; Liu, Ruzhang; McCleod, Michael; Motiwala, Hashim; Aubé, Jeffrey. In Comprehensive Organic Synthesis, 2nd Ed; Elsevier Limited: Amsterdam, 2014; 598-635. https://doi.org/10.1016/B978-0-08-097742-3.00623-6
1. “Use of a tandem Prins/Friedel-Crafts reaction in the construction of the indeno-tetrahydropyridine core of the haouamine alkaloids: formal synthesis of (-)-haouamine A.” Fenster, Erik; Fehl, Charlie; Aubé, Jeffrey. Org. Lett. 2011, 13, 2614. DOI: 10.1021/ol200725m
Patents
4. “GLYCAN DETECTION METHODS, COMPOSITIONS, AND APPLICATIONS THEREOF.” Oseni Kadiri, Yimin Liu, and Charlie Fehl. United States Provisional Patent, filed Jun 28, 2024. (number 63/665,986)
3. “Glycan Proximity Labeling Methods and Applications Thereof.” Zachary M. Nelson and Charlie Fehl. WO2025/007142A2 (January 2, 2025).
2. “Controlled Glycan Metabolic Engineering Systems and Applications Thereof.” Courtney Kondor, Jaggaiah Gorantla, Garry Leonard, and Charlie Fehl. WO2025/007135A2 (January 2, 2025).
1. “Inhibitors of CYP17A1.” Fehl, Charlie; Scott, Emily E.; Aubé, Jeffrey. United States Patent 9,611,270. (April 4, 2017)